100 cases in acute medicine:

100 cases in acute medicine is a book that will help you to gain your knowledge during the situation like acute dangerous patient conditions.

 

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Takeaway:

Acetaminophen did not have a clinically significant effect for the treatment of osteoarthritis (OA) pain in this meta-analysis of 76 randomized clinical trials (RCTs).

Why this matters:

NSAIDs are a mainstay of OA treatment, but drug selection in light of risks and polypharmacy can be difficult.

Key results:

Diclofenac 150 mg/d was the most effective intervention for pain and physical function.

Etoricoxib 60 mg/d or rofecoxib 25 mg/d also made a clinically important difference.

All NSAIDs displayed significant gastrointestinal and cardiovascular harm.

Acetaminophen did not have a clinically significant effect vs placebo at any dose.

Study design:

Network meta-analysis of 76 RCTs (n=58,451) that compared varying NSAID doses head-to-head or vs placebo or acetaminophen for hip or knee OA.

Most follow-up durations were ≀3 mo.Most trials were of high quality.

Primary outcome was pain.

Funding:
Swiss National Science Foundation;
Arco Foundation, Switzerland.

Limitations:

Many RCTs found to be at risk for some form of bias.

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