MUST KNOW FACTS ABOUT RICKETS FOR YOUR USMLE/FMGE EXAM PREPARATIONS

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MUST KNOW FACTS ABOUT RICKETS FOR YOUR USMLE/FMGE EXAM PREPARATIONS

1) Most common cause of rickets is nutritional deficiency of vitamin D…… Low MUST KNOW FACTS ABOUT RICKETSCalcium—–> High PTH—–>Low Phosphate…. : <2 years.

2) Most common non-nutritional cause of rickets – VITAMIN D-RESISTANT RICKETS…. X-linked dominant…..Everything is normal but PHOSPHATE LEVEL IS VERY VERY VERY LOW.…… >2 years

3) X-linked dominant diseases: xd rickets, incontentia pigmenti, fragile-x, 

MUST KNOW FACTS ABOUT RICKETS

charcotmarrie tooth disease, Rett disease.

4) Spine and teeth abnormalities are more prominent in VIT-D RESISTANT RICKETS; whereas head and thorax (rosary) deformities are more common in Nutritional rickets……………

5) Vitamin D-dependant rickets is AUTOSOMAL RECESSIVE disease having two types

type-1 (Renal deficincy of 1-a-hydroxylase)

type-2: end organ resistance everywhere and increased 1-25 d3.

 

6) VITAMIN D-RESISTANT RICKETS and Type-2 vitamin D depentant both have end organ resistance but the difference is VIT-D-R has resistance mostly in kidney leading to LOW PHOSPHATE while Type-2 vit.d.depented has resistance in every part of body and it also leads to ALOPECIA.

 

 

 

MUST KNOW FACTS ABOUT RICKETS

7) Best site to do X-RAY for findings of rickets is WRIST……… IN ACTIVE RICKETS:
CUPPING, FRAYING, FLARING ; decreased bone density; …………… IN HEALING
RICKETS: preparatory line of calcification, calcification of osteoid.

 




8) For treatment of RICKETS…… give Inj Vit.D3 2 lac unit i/m…… after 2 weeks: do
x-ray and see improvement : if no improvement….again repeat…. after that..
maintenance dose of 400 IU daily.

 

9) If after 2 injections of vit-d there is no improvement = VIT-D RESISTANT
RICKETS……Rx by Oral PHOSPHATE SUPPLEMENTS and 1,25 vit-d3.

 

10) Rosary (prominent costocondral junction) is also found in SCURVY as
well………. but scurvy has other findings as well which are = PARAFOLLICULAR
HEMORRHAGES; FROG POSITION OF LEGS and leg pain; …….. X-RAY: Ground glass,Pencil point cortex, White line of Ferenkel…..”

credits:shaheryar