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First Aid for the Basic Sciences: Organ Systems 3rd Edition

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First Aid for the Basic Sciences: Organ Systems 3rd Edition

FRANK-STARLING RELATIONSHIP  First Aid for the Basic Sciences: Organ Systems 3rd Edition pdf

The greater the venous return, the greater the cardiac output. It can be thought of as the length-tension relationship applied to the whole heart: The force of systolic contraction is proportional to the initial length of cardiac muscle in diastole (preload).
• Molecular/cellular level: Sarcomere length is proportional to the force of contraction that it can generate: The longer it is, the more cross-bridges that form, and the greater the tension that can develop. The increased stretch that the myocytes see when the ventricle is filled translates into optimized overlapping of the actin-myosin filaments, which generate increasing force of contraction when the cross-bridges recycle. Up to a certain point, the increased stretch/preload leads to greater contractility.
• Organ level: Increased venous return or end-diastolic volume (preload)
leads to increased ventricular fiber length and increasing tension, which increases stroke volume and cardiac output. The Frank-Starling curve can be shifted up or down when the heart is in a state of increased or decreased
contractility, ..

one of the best 2017 usmle books that every student must have..

• An essential companion during your first two years of medical school
• Includes important foundational content most other reviews leave out
• Focuses on the high-yield topics and facts tested on the USMLE Step 1
• Enhanced by full-color images, learning aids, tables, and concise text to streamline your study and help you excel in coursework and on the USMLE Step 1
• Provides a complete framework for understanding biochemistry, microbiology, immunology, pathology, pharmacology, and public health sciences
• Mirrors the table of contents of First Aid for the USMLE Step 1 to facilitate side-by-side study
• Written by students who aced the USMLE and reviewed by top faculty

 

Be sure to also get Dr. Le’s First Aid for the Basic Sciences: Organ Systems, Third Edition

 First Aid for the Basic Sciences: Organ Systems 3rd Edition PDF

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