Coronary artery disease from biological to clinical practice Latest Edition PDF
Coronary artery disease from biological to clinical practice Latest Edition PDF I am delighted to write the preface of this excellent book authored by Professor Tousoulis. Despite the considerable advances in the diagnosis, medical treatment, and interventional strategies, ischemic heart disease remains the main cause of mortality and morbidity worldwide, whereas risk factors explain only part of the disease spectrum. A better knowledge of ischemic heart disease pathophysiology might have a considerable impact on clinical management. The purpose of this book is to link basic science (genetic and molecular mechanisms) with clinical practice for the benefit of both patients and physicians. To achieve these goals, this book is organized into three chapters. The first chapter is focused on the mechanisms leading to atheroma formation and progression with specific regard to the complex interaction among genetics, risk factors, inflammation, and oxidative stress.
Coronary artery disease from biological to clinical practice Latest Edition PDF The second chapter is focused on the physiology and pathophysiology of coronary circulation with specific regard to the mechanisms responsible for the mismatch between perfusion and function, which is responsible for myocardial ischemia. The mechanisms leading to acute coronary thrombosis are also elucidated. The third chapter is focused on the therapeutic challenges and unmet needs in the treatment of stable ischemic heart disease and of acute coronary syndromes. The initial sections of this chapter are dedicated to potential new treatments targeting inflammation and oxidative stress not yet tested in large randomized trials but supported by strong pathophysiological observations.
Coronary artery disease from biological to clinical practice Latest Edition PDF The later sections in the chapter address the potential of gene and stem cell therapy for patients not amenable to conventional anti-ischemic treatments. In addition, this chapter addresses the utilization of invasive and noninvasive techniques for the assessment of anatomic and functional alterations of coronary circula- tion. Finally, this chapter critically discusses traditional and novel coronary revasculariza- tion strategies. I strongly recommend this book to students, internists, and cardiologists with an interest in ischemic heart disease from prevention to the management of acute coronary syndromes. The translational approach, the emphasis on pathophysiology, and the focus on unmet needs and potential innovative treatments make this book very appealing for both the present and future of ischemic heart disease.
Thanks to the best author Dr.DIMITRIS TOUSOULIS