Download Psoriasis and Psoriatic Arthritis Pathophysiology, Therapeutic Intervention, and Complementary Medicine Ebook PDF
Download Psoriasis and Psoriatic Arthritis Pathophysiology, Therapeutic Intervention, and Complementary Medicine Ebook PDF Psoriasis is a lifelong chronic autoimmune disorder, a chronic heterogeneous skin pathophysiol- ogy characterized by thick, scaly skin lesions and accompanied by massive in ammation, exten- sive hyperproliferation of keratinocytes, scaly plaques, and erythema. In psoriasis lesions, skin cells (keratinocytes) grow too quickly, resulting in thick, white, silvery, or red patches on the skin. Generally, skin cells grow gradually and ake off about every 4 weeks. New skin cells grow to replace the outer layers of the skin as they shed. However, in psoriasis, new skin cells move rapidly to the surface of the skin in days rather than weeks. They build up and form thick patches known as plaques. The patches range in size from small to large. They most often appear on the elbows, scalp, feet, knees, hands, or lower back, or as the more embarrassing aking of the skin and/or patches on the face. Generally, psoriasis is most common in adults, but teenagers and children can also suffer from it.
Download Psoriasis and Psoriatic Arthritis Pathophysiology, Therapeutic Intervention, and Complementary Medicine Ebook PDF Psoriasis is not just a skin condition; it begins underneath the skin. It is a chronic disease of the immune system. Psoriasis is frequently associated with a severe form of arthritis. In other words, psoriatic arthritis is a chronic form of in ammatory arthritis accompanied by psoriasis. Psoriasis and psoriatic arthritis together are considered psoriatic diseases. Several comorbidities are associ- ated with psoriatic disease, such as type 2 diabetes, metabolic syndrome, cardiovascular disease, and depression.
Download Psoriasis and Psoriatic Arthritis Pathophysiology, Therapeutic Intervention, and Complementary Medicine Ebook PDF Several pharmaceutical therapeutics and treatment options are available for psoriasis and pso- riatic arthritis. This book demonstrates a signi cant number of treatment modalities available for psoriasis and psoriatic arthritis. Currently, nutraceuticals and functional food-based formulations are becoming popular for almost every medical condition. Here we have invited several leading authorities to contribute their opinion on nutraceuticals and functional food-based therapy for pso- riasis and psoriatic arthritis.
A total of 21 chapters have been compiled in this book involving global leaders in the eld. The rst two sections present an extensive discussion of the epidemiology, genetics, pathogenesis, and in ammatory sequences of psoriasis; the association of the metabolic syndrome; angiogenesis and the roles of adhesion molecules; the regulatory role of Th17 cells; and the nerve growth factor and its recep- tor system.
Section III emphasizes the clinical pro les, including the clinical spectrum of psoriasis and spondyloarthritis, comorbidities in psoriatic arthritis.
Section IV, Part A, highlights the treatment regimen in seven discrete chapters, including the current treatment recommendations for psoriasis, the management of psoriatic arthritis, intricate aspects and the role of IL-23/IL-17 inhibitors, the roles of disease-modifying antirheumatic drugs, topical therapies, JAK-STAT pathophysiology, and nally, the concept of total care, which is a mul- tidisciplinary approach for the management of psoriatic disease.
Section IV, Part B, includes three classic chapters highlighting the bene cial roles of nutraceuti- cal components, herbal products, and the impact of nutrition and dietary supplements on psoriasis pathology. Bioactive whey extract has demonstrated the presence of growth factors, active pep- tides, and immunoglobulins that block skin in ammation by inhibiting the actions of tumor necro- sis factor-alpha and in ammatory cascade at the molecular level. Several antioxidants, including alpha lipoic acid, N-acetyl cysteine, glutathione, curcumin and turmeric, astaxanthin, and several structurally diverse antioxidants, demonstrate a potential natural therapeutic strategy for psoriasis. Nutraceutical therapeutic options are far less expensive and not associated with adverse side effects.
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