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Download pathoma pathology 2017 Slides Ebook PDF

Download pathoma pathology 2017 Slides Ebook PDF

Download pathoma pathology 2017 Slides Ebook PDF

Download pathoma pathology 2017 Slides Ebook PDF  Inflammation is the response of living tissues to cellular injury. It involves both innate and adaptive immune mechanisms.

Inflammation can be divided into two types: acute and chronic. The division of inflammation is based according to the time course and cellular components involved. These categories are not mutually exclusive, and some overlap exists (Fiagents, e.g. trauma, heat, cold, ultraviolet light, radiation

• irritant and corrosive chemical substances, e.g. acids, alkalis
• microbial infections, e.g. pyogenic bacteria
• immune-mediated hypersensitivity reactions, e.g. immune-mediated vasculitis, seasonal allergic rhini-
tis (hay fever)
• tissue necrosis, e.g. ischaemia resulting in a myo-
cardial infarction.
Causes of chronic inflammation
Chronic inflammation usually develops as a primary response to:
• microorganisms resistant to phagocytosis or intra- cellular killing mechanisms, e.g. tuberculosis (TB), leprosy
• foreign bodies, which can be endogenous (e.g. bone, adipose tissue, uric acid crystals) or exogenous (e.g. silica, suture materials, implanted prostheses)
• some autoimmune diseases, e.g. Hashimoto’s thy- roiditis, rheumatoid arthritis, contact hypersensitiv- ity reactions
• primary granulomatous diseases, e.g. Crohn’s dis- ease, sarcoidosis.

Download pathoma pathology 2017 Slides Ebook PDF  Inflammation becomes chronic when it occurs over a prolonged period of time with simultaneous tissue destruction and attempted repair. It may occur second- ary to acute inflammation due to the persistence of the causative agent. Figure 2.2 shows the sequelae of inflammation.

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