DRUG METABOLISM IN DISEASES Ebook PDF download
DRUG METABOLISM IN DISEASES Ebook PDF download am very happy to present you with this
special topic book titled Drug Metabolism in Diseases.
Drug metabolism is essential for both
drug therapy and drug safety. In addition to the genetic and environmental factors, diseases and physiological states of patients have profound effects on drug metabolism and disposition. Examples of diseases known to affect drug metabolism include
liver and kidney diseases, inflammation and sepsis, cardiovascular diseases, and diabetes.
Physiological conditions that can affect drug metabolism exist in pediatric and pregnant populations, and patients in critical care, among others. Understanding the patho-
physiological effect on drug metabolism will help to guide better and safer use of clinical drugs. Armed with the knowledge of disease effects on drug metabolism, the use of drugs can be tailored to specific diseases or physi-
ological conditions, which is highly relevant to personalized medicine and precision medicine. For these reasons, there is agreat
need for a book in this area. The topics
mentioned earlier have been systemically
covered in this book.
Another key feature of this book is the
mechanistic insights by which diseases
and physiological states affect drug meta-
bolism. Examples of the mechanistic
insights throughout the chapters include
pharmacogenetics, xenobiotic receptors,
nuclear receptors, transcriptional regulation of genes encoding drug metabolizing enzymes and transporters, crosstalk between xenobiotic metabolism and endobiotic metabolism, as well as the reciprocal effect of the expression and activity of drug metabolizing enzymes and transporters on the clinical outcome of diseases. Understanding these mechanistic insights is paramount in harnessing the benefits of the knowledge communicated in this book and to improve the effective and safe use of drugs in the.