THE SCIENTIST’S GUIDE TO CARDIAC METABOLISM Ebook PDF download

THE SCIENTIST’S GUIDE TO CARDIAC METABOLISM Ebook PDF download Jan Glatz and Miranda Nabben begin with illustrating basics in metabolically relevant biochemistry. They show that metabo-lism is tightly coupled to all major types of bio-molecules as virtually every biomolecule can be used as a substrate or pathway component in metabolism. Carbohydrates and fatty acids are the main substrates used to produce ATP.

Amino acids and nucleotides are mainly used to build proteins and nucleic acids. However, all biomolecules come with specific characteristics and even when they are “exclusively” used as substrate for ATP generation, their biochemical influence on other cellular processes needs to be taken into account as well. Furthermore, the properties of biomolecules influence their trans-port as well as their import into the cell or into cellular substructures, such asmitochondria.
Fatty acids as lipophilic compounds are not readily soluble in the aqueous blood and cyto-plasm. Carbohydrates, nucleic acids, and amino acids are more hydrophilic and may not cross membranes without help. Thus, it is important o be aware of the properties of biomolecules and their biochemistry. This chapter introduces  the reader to the biochemical properties of the  major classes of molecules and illustrates their behaviour.

THE SCIENTIST’S GUIDE TO CARDIAC METABOLISM Ebook PDF download