A Guide to Gastrointestinal Motility Disorders PDF download

A Guide to Gastrointestinal Motility Disorders PDF download

A Guide to Gastrointestinal Motility Disorders PDF download The objective of this Atlas is to introduce the structure and distributions of interstitial cells of Cajal (ICC) to researchers, clinicians and students of biomedical fields who are interested in the motility of the gastrointestinal (GI) tract and the regulatory mechanism of the smooth muscle in general. Recent development of ICC studies have broadened the research horizon from only the GI tract to other hollow organs with smooth muscle coats outside GI tract, and the presence or absence of ICC and their functional states in these organs are often discussed in the context of a variety of diseases.

However, there have been difficulties to understand whole morphological characteristics of ICC by conventional histological sections or ultrathin sections because of their peculiar shape, the presence of long slender processes projecting from the cell bodies similar to neurons. This is a reason why earlier histologists misunderstood ICC as neurons. Another reason for the difficulty is the presence of ICC subtypes that show different distributions and different ultrastructural features depending on the levels of the GI tract. Therefore, a detailed morphological guide for ICC in each organ of the GI tract is necessary for starting to understand ICC
A stable morphological foundation is essential for understanding the function of tissues and organs and for interpreting their changes in disease.

A Guide to Gastrointestinal Motility Disorders PDF download

For this Atlas, I assembled many images of whole-mount stretch preparations stained with immunohistochemistry. Such preparations are among the most useful to reveal the whole shape of ICC in a similar way to the silver impregnation method for nerves used in traditional histology. Stereo-micrographs reconstructed from confocal microscopic images of ICC are especially helpful for understanding their three-dimensional (3D) structures in situ to readers who are unfamiliar with the morphology of GI tract in general and ICC in particular. Electron micrographs contained in this book reveal a more precise character of ICC as a peculiar cell type and provide clues for discussing their functional aspects. The approaches presented here effectively display the whole characteristics of ICC. Some functional aspects of ICC are described in the relevant sections and a miminal number of literature citations are listed.

I still remember the strong impression I got when I read the paper on ICC and his pacemaker hypothesis by Lars Thuneberg (1982), since I had also published a small paper on ICC in the extension of the studies of the enteric nervous system at almost the same time. My work was based simply on my cytological interest using modern ultrastructural observations of ICC trying to get an answer to a long-standing puzzle of whether ICC are neurons or glial cells or connective tissue cells. This great shock made me determined to examine Thuneberg’s hypothesis rather skeptically. However, I gradually accumulated evidence to support his idea.

A Guide to Gastrointestinal Motility Disorders PDF download