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Essentials of RUBIN’S PATHOLOGY SIXTH EDITION PDF

Essentials of RUBIN’S PATHOLOGY SIXTH EDITION PDF

Essentials of RUBIN’S PATHOLOGY  SIXTH EDITION PDF

Essentials of RUBIN’S PATHOLOGY SIXTH EDITION PDF Pathology is the study of structural and functional abnor-
malities that are expressed as diseases of organs and systems.

Classic theories attributed diseases to imbalances or noxious  effects of humors on specifi c organs. In the 19th century,  Rudolf Virchow, often referred to as the father of modern  pathology, proposed that injury to the smallest living unit  of the body, the cell, is the basis of all disease. To this day,  clinical and experimental pathology remain rooted in this  concept, which is now extended by an increased understanding of the molecular nature of many disease processes.

A living cell must maintain the ability to produce  energy, much of which is spent in establishing a barrier  between the internal milieu of the cell and a hostile environment.

The plasma membrane, associated ion pumps and receptor molecules serve this purpose. A cell must also  be able to adapt to adverse environmental conditions, such  as changes in temperature, solute concentrations, oxygen  supply, the presence of noxious agents and so on. If an injury exceeds the adaptive capacity of the cell, the cell dies.
From this perspective, pathology is the study of cell injury  and the expression of a cell’s pre-existing capacity to adapt
to such injury.

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Essentials of RUBIN’S PATHOLOGY SIXTH EDITION PDF

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