Harper’s illustrated Biochemistry Thirty First Edition 31e eBook PDF Free Download
Harper’s illustrated Biochemistry Thirty First Edition Biochemistry and medicine enjoy a mutually cooperative relationship.
Biochemical studies have illuminated many aspects of health and disease,
and the study of various aspects of health and disease has opened up new
areas of biochemistry.
The medical relevance of biochemistry both in normal and abnormal situations is emphasized throughout this book.
Biochemistry makes significant contributions to the fields of cell biology,
physiology, immunology, microbiology, pharmacology, toxicology, and
epidemiology, as well as the fields of inflammation, cell injury, and
cancer. These close relationships emphasize that life, as we know it,
depends on biochemical reactions and processes.
Harper’s illustrated Biochemistry Thirty First Edition
Let’s Talk about water
Water is the predominant chemical component of living organisms. Its
unique physical properties, which include the ability to solvate a wide range of organic and inorganic molecules, derive from water’s dipolar structure and exceptional capacity for forming hydrogen bonds. The manner in which water interacts with a solvated biomolecule influences the structure both of the biomolecule and of water itself.
An excellent nucleophile, water is a reactant or product in many metabolic reactions. Regulation of water balance depends upon hypothalamic mechanisms that control thirst, on antidiuretic hormone (ADH), on retention or excretion of water by the kidneys, and on evaporative loss.
Nephrogenic diabetes insipidus, which involves the inability to concentrate urine or adjust to subtle changes in extracellular fluid osmolarity, results from the un responsiveness of renal tubular osmoreceptors to ADH.